Coronary Artery Bypass Surgery. Atherosclerotic heart disease
Conditions
Interventions
Intervention 1: 1 µg/kg sufentanil is injected in post-conditioning group through the cardiopulmonary cannula 5 minutes before Cross Clamp and then cold blood cardioplegia solution with antigrad metho
Treatment - Drugs
1 µg/kg sufentanil is injected in post-conditioning group through the cardiopulmonary cannula 5 minutes before Cross Clamp and then cold blood cardioplegia solution with antigrad method will be inject
In the control group, patients receive 5 cc normal saline through the cardiopulmonary cannula 5 minutes before Cross Clamp and then cold blood cardioplegia solution with antigrad method will be inje
Sponsors
Vice Chancellor for Research, Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion Criteria :20-65-year-old adults undergoing elective CABG. Exclusion criteria: History of preceding arrhythmia; Ejection fraction less than 35%; recent myocardial infarction (less than 6 months); renal or liver failure; permanent or temporary pacemaker; hypertension; AV block or bradycardia less than 50 heart beat In minutes; congestive heart failure (CHF); re-operation; history of diabetes.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The serum level of CPK-MB enzymes, troponin I. Timepoint: at the induction of anesthesia 6, 12, and 24 hours after surgery. Method of measurement: Arterial blood sample.;Inotropic scores criteria. Timepoint: After arrival to the ICU and inthe operating room. Method of measurement: Observasion. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehdi Tahari
Shiraz University of Medical Sciences
Outcome results
None listed