Coronary Artery Bypass Surgery. Atherosclerotic heart disease
Conditions
Interventions
Intervention 1: Patients in the study group received 80 mg atorvastatin daily, for 3 days before surgery and low dose of 20 mg atorvastatin daily during the ICU stay, after surgery, and after discharg
Treatment - Drugs
Patients in the study group received 80 mg atorvastatin daily, for 3 days before surgery and low dose of 20 mg atorvastatin daily during the ICU stay, after surgery, and after discharge, the treatment
patients in the control group received 20 mg atorvastatin up to surgery and during the one month follow up period they continued their medication with 20 mg atorvastatin daily.
Sponsors
Vice Chancellor for Research, Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients who had been taking (atorvastatin 20 mg daily) at least one year prior to the cardiac surgery. Exclusion criteria: unstable angina; evidences of recent MI (within 6 months) ; history of cardiac surgery; congenital heart disease; history of cardiac arrhythmia (arterial fibrillation) before surgery; receiving anti- arrhythmic drugs (except Beta blockers) ; having pacemaker; left ventricle ejection fraction less than 30%, uncontrolled hypertension; arterial or ventricular arrhythmia; pregnancy; patient who are undergoing diabetes treatment; increased level of liver enzymes; renal failure with creatinine more than 2 mg/dl; active inflammation or immune deficiency; positive history of muscle disease or reaction to the stations.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The serum level of CPK-MB enzymes, troponin I. Timepoint: before induction of anesthesia and 24 ,48 hours after surgery. Method of measurement: Arterial blood sample.;High-sensitivity C-reactive protein (hs-CRP) levels,. Timepoint: before induction of anesthesia and 24 ,48 hours after surgery. Method of measurement: Arterial blood sample.;Mechanical ventilation duration in the ICU. Timepoint: After arrival to the ICU. Method of measurement: Observasion. | — |
Secondary
| Measure | Time frame |
|---|---|
| Glomerular filtration rate (GFR) and urine output. Timepoint: After surgery in the intensive care unit. Method of measurement: observasion.;Blood glucose. Timepoint: After surgery in the intensive care unit. Method of measurement: blood sample. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMisagh Bastani
Shiraz University of Medical Sciences
Outcome results
None listed