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The effectiveness of oral symbiotic on Inflammation in the large intestine of neonates

A comparative study of bowel Candida albicans colonization in neonates with less than 2500 g weighing after taking an oral synbiotic and placebo

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2017080614333N79
Enrollment
102
Registered
2017-08-16
Start date
2017-08-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm infant. Other preterm infants

Interventions

Intervention 1: The intervention group will receive 5 drops of synbiotic that dropped in the mouth or mixed with milk for seven to ten days. Intervention 2: The control group will receive 5 drops of d
Treatment - Drugs
Placebo
The intervention group will receive 5 drops of synbiotic that dropped in the mouth or mixed with milk for seven to ten days.
The control group will receive 5 drops of distilled water for seven to ten days

Sponsors

Vice chancellor for research, Kermanshah University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
6 Months to 3 Days

Inclusion criteria

Inclusion criteria: Inclusion criteria: Birth weight 2500 grams and less; Age of admission time 72 hours and less; Non-use of oral and topical antifungals during the last month of pregnancy. Exclusion criteria: Prohibition of oral intake such as congenital anomalies of the jaw and mouth and digestive system; Presence of confirmed neonatal necrotizing enterocolitis; Sepsis; Simultaneous intake of antifungal or injecting drugs such as fluconazole; nystatin and amphotericin in the baby; Use of dairy products containing prebiotic or probiotic in the neonate, and coagulation or liver tests of disturbed randomized Gastroesophilia and Amphalocell prior to reconstructive surgery.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Infection. Timepoint: At the beginning of the study, seven to ten days after the start of the study. Method of measurement: Stool culture.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Mohammadi

Kermanshah University of Medical Sciences

mohammadi.m@gmail.com+98 83 3721 8202

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026