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Clinical Trial Study of the Effect of Apripitant Drug on Nausea and Vomiting Due to Chemotherapy in Children

The Effect of Aprepitant on Chemo-Induced Nausea and Vomiting in Children with Cancer

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2017080520715N3
Enrollment
60
Registered
2017-09-05
Start date
2017-08-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nausea and vomiting. Nausea and vomiting of children

Interventions

Intervention 1: Each patient receives the same for an hour before the first course of 40 mg/kg body weight chemotherapy in the form of a single dose of granisetron to a maximum dose of 3 mg per dose p
Treatment - Drugs
Placebo
Each patient receives the same for an hour before the first course of 40 mg/kg body weight chemotherapy in the form of a single dose of granisetron to a maximum dose of 3 mg per dose plus placebo on d
In the control group, similar placebo was used.

Sponsors

Vice chancellor for research, Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
5 Years to 18 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Patients with malignancies who was under chemotherapy with 5 to 18 years of age; non-nausea due to illness with the approval of the physician; presence of a healthy vision; attending the first day of chemotherapy and nausea severity; minimum score of 20 From VAS mm100 (visual analogue scale). Exclusion criteria: Severe manifestations of complications of the epiphyte including fever, severe infection, tinnitus, deep vein thrombosis, severe digestive problems, etc; failure of the patient to determine the severity of nausea based on the instructions.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Nausea and vomiting. Timepoint: 1, 2nd and 3rd days. Method of measurement: Recorded in checklist.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAziz Eghbali

Amir Kabir Hospital of Arak city

dr.eghbali@arakmu.ac.ir+33 135075

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026