Comparison of the effect of mannitol and hypertonic sodium administration to reduce ICP on hemodynamic parameters

Comparison of the effect of mannitol and hypertonic sodium administration to reduce ICP on hemodynamic parameters under LiDCO monitoring in patients undergoing elective craniotomy

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170805035510N7

Enrollment

Registered

2022-01-20

Start date

2022-02-20

Completion date

Unknown

Last updated

2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Craniotomy.

Interventions

Intervention 1: Intervention group: Receive 5 ml / kg mannitol 20% by slow intravenous injection after induction of anesthesia. Intervention 2: Intervention group: Receive 3 mg / kg of hypertonic seru

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: ASA class 1,2 Elective Craniotomy

Exclusion criteria

Exclusion criteria: previous craniotomy pregnancy morbid obesity(BMI>40) Na>160 Hb<10 Patients treated with hyperosmotic fluids 24 hours before surgery

Design outcomes

Primary

Measure	Time frame
Pulse pressure variation. Timepoint: Every 20 min. Method of measurement: Advance Hemodynamic Monitoring.;Stroke volume variation. Timepoint: Every 20 min. Method of measurement: Advance Hemodynamic Monitoring.	—

Secondary

Measure	Time frame
Acidosis. Timepoint: Every 1 hour. Method of measurement: Blood Gas Analysis.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactPejman Pourfakhr

Tehran University of Medical Sciences

pourfakhr@tums.ac.ir+98 21 6312 1539

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026