A clinical trial comparing the preventive effect of Ondansetron and Dexamethasone on control of headache caused by local anesthetic from the lumbar in non-emergency cesarean section

Comparison prophylactic effect of Ondansetron and Dexamethasone in management post- dural puncture headache (PDPH) in women candidated for elective Cesarean

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170802035464N2

Enrollment

120

Registered

2018-07-04

Start date

2017-06-22

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

elective cesarean section. Delivery by elective caesarean section

Interventions

Intervention 1: We inject 8 milligram Dexamethasone slow intravenously. Intervention 2: We inject 8 milligram Ondansetron slow intravenously. Intervention 3: We inject 8 milligram distilled water as

Eligibility

Sex/Gender

Female

Age

17 Years to 17 Years

Inclusion criteria

Inclusion criteria: Informed consent Elective repeated (second) cesarean section Candidate ?cesarean with spinal anesthesia

Exclusion criteria

Exclusion criteria: Lack of consent Candidate cesarean with general anesthesia Drug allergy Emergency cesarean section

Design outcomes

Primary

Measure	Time frame
Headache. Timepoint: 12, 24 and 48 hours after cesarean. Method of measurement: Visual Analogue Scale of pain.	—

Secondary

Measure	Time frame
Blood pressure. Timepoint: Every 15 minute until end of recovery. Method of measurement: Sphygmomanometer (millimeter Hg).;Heart rate. Timepoint: Every 15 minute until end of recovery. Method of measurement: Beat in minute.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Alireza Kamali

Arak University of Medical Sciences

alikamaliir@yahoo.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026