"Evaluation of the effect of oral acetaminophen on the treatment of neonatal PDAs"

Comparison of the effect of oral Acetaminophen with oral Ibuprofen in closure of Patent ductus arteriosus (PDA) in preterm neonate with gestational age less than 32 weeks

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170801035441N1

Enrollment

Registered

2018-07-09

Start date

2018-06-22

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patent ductus arteriosus. Patent ductus arteriosus

Interventions

Intervention 1: Intervention group: For 48 hours, Drop of Acetaminophen made by the kimia gar Pharma Company at a dose of 15 mg / kg every 6 hours, given through the NG tube or through the dropper, by

Eligibility

Sex/Gender

All

Age

1 Days to 14 Days

Inclusion criteria

Inclusion criteria: All neonate with 32 weeks or less requiring PDA treatment for clinical conditions PDA is confirmed by echocardiography Age less than 14 days

Exclusion criteria

Exclusion criteria: Congenital heart disease Clinical and laboratory symptoms of sepsis Chromosomal or congenital abnormalities The presence of Ibuprofen is contraindicated

Design outcomes

Primary

Measure	Time frame
The closure rate of patent ductus arteriosus (PDA). Timepoint: Echocardiography at the beginning of the study and then 48-72 hours after treatment. Method of measurement: Confirmed by echocardiography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmir Banazade

Esfahan University of Medical Sciences

amir_banazade@yahoo.com+98 31 3668 5321

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026