Effects of Autologus Platelet- Rich Plasma on ICSI outcomes and Pregnancy Rate in frozen embryo transfer cycles in Repeated Implantation Failure Patients

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017073034422N2

Enrollment

Registered

2017-10-16

Start date

2017-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility, recurrent implantation failure. Complication associated with artificial fertilization, unspecified

Interventions

Intervention 1: In intervention group, PRP will be done for patient 48 hours before embryo transfer. For PRP, 8.5 cc of peripheral blood will be given and the number of platelet will be checked. Then

Treatment - Other

In intervention group, PRP will be done for patient 48 hours before embryo transfer. For PRP, 8.5 cc of peripheral blood will be given and the number of platelet will be checked. Then the blood will b

In control group, the embryo transfer catheter will be inserted for patient 48 hours before embryo transfer and will be removed without injection of anything.

Eligibility

Sex/Gender

Female

Age

20 Years to 41 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patient who has at least 2 cycle IVF failure; At least 6 good quality embryos were transferred in previous cycles; Semen count=10 millions,normal morphology =3% in semen analysis Exclusion criteria: 1-patient without immunologic disorders (abnormality in CD markers, Anti TG, Anti TPO, ds DNA, ANA); hematologic disorder; genetic diseases; uterus disorders; Hb<11 mg/dl and Platelet<150000/mm3; use of corticosteroid during 14 days before of PRP

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Chemical pregnancy rate. Timepoint: Two weeks after intervention. Method of measurement: Beta HCG in blood.	—

Secondary

Measure	Time frame
Implantation Rate. Timepoint: Six weeks after intervention. Method of measurement: Calculation (number of embryos transfer /number of pregnancy sacs in sonography 6 weeks after ET).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSheyda Jouhari

Avicenna Infertility Clinic

s.jouhari@ari.ir info@avic.ir+98 21 23519

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026