Rheumatoid arthritis. Rheumatoid arthritis, unspecified
Conditions
Interventions
Intervention 1: intervention group: N-acetylcysteine 600 mg twice daily for 12 weeks. Intervention 2: control group: Placebo twice daily for 12 weeks.
Treatment - Drugs
Placebo
intervention group: N-acetylcysteine 600 mg twice daily for 12 weeks
control group: Placebo twice daily for 12 weeks
Sponsors
Vice Chancellor for research of Hamadan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: inclusion criteria: Patients with active rheumatoid arthritis; Normal renal function(serum creatinine lower than 2); Ability of taking oral n-acetylcysteine; Normal liver function exclusion criteria: Renal dysfunction; Liver dysfunction; Active infection; Mental or cognitive problem; Disability of taking oral drug; Taking antioxidant agents or anti-inflammatory drugs in previous month; Patients with other inflammatory diseases; Patients whom experience adverse drug reactions; Pregnant or lactating patients
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nitric oxide. Timepoint: at baseline, at the end of study. Method of measurement: serum level.;Lipid peroxidation. Timepoint: at baseline, at the end of study. Method of measurement: serum level.;Thiol groups. Timepoint: at baseline, at the end of study. Method of measurement: serum level.;Total antioxidant capacity. Timepoint: at baseline, at the end of study. Method of measurement: serum level. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Mehrpooya
Hamedan University of Medical Sciences
Outcome results
None listed