Comparison of Extra Virgin Olive Oil and Canola Oil in Treatment of Patients with Ulcerative Colitis(UC)

Comparison of Extra Virgin Olive Oil and Canola Oil on Clinical Outcomes and Inflammatory Markers (hsCRP, TNF-a) among Patients with Ulcerative Colitis(UC)

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170730035381N1

Enrollment

Registered

2017-12-28

Start date

2018-01-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ulcerative colitis. Ulcerative colitis

Interventions

Intervention 1: Extra virgin olive oil

50 ml once daily

Crossover intervention for 20 days and 14 days wash out

with food in raw form (no frying and cooking oil)

Aryan Tame Khazar Co. Intervention 2: Intervention group: Canola oil

Aryan Tame Khazar Co.

Treatment - Other

Extra virgin olive oil

Intervention group: Canola oil

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Ulcerative colitis, confirmed by histopathology The severity of the disease is mild to moderate Non-infectious, autoimmune and inclusive diseases (including cancer, kidney disease, rheumatoid arthritis, liver, AIDS, and cardiovascular disease) No use of ?3 supplements, fish oil Body mass index ranges from 18.5 to 30 The patient should not be pregnant or breastfeeding The age range is between 18 and 75 years old People's Inclination to collaborate on the plan

Exclusion criteria

Exclusion criteria: The patient is in the acute phase of the disease The patient does not tolerate the recommended oils reluctancy to continue cooperation in this research

Design outcomes

Primary

Measure	Time frame
Serum hs-CRP. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: ELISA.;Serum TNF-a. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: ELISA.;Serum ESR. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: ELISA.;Stool frequency per day. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: Mayo score.;Frequency of rectal bleeding per day. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: Mayo score.	—

Measure

Time frame

Serum hs-CRP. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: ELISA.;Serum TNF-a. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: ELISA.;Serum ESR. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: ELISA.;Stool frequency per day. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: Mayo score.;Frequency of rectal bleeding per day. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: Mayo score.

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Secondary

Measure	Time frame
Weight. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: Scales.;Body mass index. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: BMI by formula.;Waist circumference. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: Non stretch meter.;Hip circumference. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: Non stretch meter.	—

Measure

Time frame

Weight. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: Scales.;Body mass index. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: BMI by formula.;Waist circumference. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: Non stretch meter.;Hip circumference. Timepoint: The beginning of the study - the end of the twentieth day. Method of measurement: Non stretch meter.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehrnaz Morvaridi

Ahvaz Jundishapur University of Medical Sciences

morvaridi.m@ajums.ac.ir+98 61 3221 6104

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026