Evaluation of effect of melatonin on the duration of mechanical ventilation in patients requiring hospitalization in the intensive care unit

Clinical trial of the effect of melatonin administration on duration of mechanical ventilation in patients requiring hospitalization in the intensive care unit

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170729035360N1

Enrollment

Registered

2018-01-11

Start date

2017-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dependence on respirator. Dependence on respirator

Interventions

Intervention 1: Prescription of melatonin, 3 mg daily, in intervention group. Intervention 2: prescription of placebo, daily, in control group.

Treatment - Drugs

Placebo

Prescription of melatonin, 3 mg daily, in intervention group

prescription of placebo, daily, in control group

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: admition in intensive care unit age older than 18 year old need for mechanical ventilation

Exclusion criteria

Exclusion criteria: Hepatic failure kidney Failure Pregnancy Brain Tumor The hypersensitivity history of melatonin Patients with GCS<4

Design outcomes

Primary

Measure	Time frame
The duration of mechanical ventilation dependence. Timepoint: daily. Method of measurement: visual.	—

Secondary

Measure	Time frame
Mortality. Timepoint: daily. Method of measurement: visual.;The duration of hospitalization in the intensive care unit. Timepoint: daily. Method of measurement: visual.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMandana Izadpanah

Ahvaz Jundishapur University of Medical Sciences

izadpanah-m@ajums.ac.ir+98 61 3373 8378

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026