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Evaluation of the effect of Famotidine in esophageal and cardiac cancer

Evaluation of the radioprotective effects of famotidine in reducing the hematologic complications of esophageal and cardiac cancers chemoradiation.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20170728035349N1
Enrollment
60
Registered
2020-08-19
Start date
2020-09-22
Completion date
Unknown
Last updated
2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Esopageal Cancer. Condition 2: Cardia Cancer. Malignant neoplasm of esophagus Malignant neoplasm of cardia

Interventions

Intervention 1: Intervention group: 30 patients, 28 days of famotidine with 28 sessions of radiotherapy. Intervention 2: Control group: 30 patients take placebo for 28 days concurrent with radiothera

Sponsors

Zanjan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 75 Years

Inclusion criteria

Inclusion criteria: All patients with non-metastatic esophageal cancer and non-metastatic cardiac cancer aged 30 to 75 years who are candidates for radiotherapy and do not receive PPIs and other H2-blocker antagonists. Aged 30 to 75 years old Being candidates for chemo radiotherapy Do not receive PPIs and other H2-blocker antagonists.

Exclusion criteria

Exclusion criteria: Patients who die during the project. Patients who are unable to continue treatment due to the severity of treatment complications. Patients who are unable to continue treatment due to the severity of treatment complications. Need to use PPI family drugs during the treatment process

Design outcomes

Primary

MeasureTime frame
Blood Complications Chemo Radiotherapy for esophageal and cardiac cancers. Timepoint: Acute blood complications of chemo radiation weekly during radiotherapy with weekly CBC diff check for 5 weeks. Method of measurement: CBC diff blood sample.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZhaleh Karimimoghaddam

Zanjan University of Medical Sciences

zhkarimi@zums.ac.ir+98 24 3302 3754

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 9, 2026