Comparison of analgesic effects of intravenous infusion of Lidocaine and Ketamine on acute pain after elective laparotomy surgery in patients of two groups of purpose and control

Evaluation of analgesic effects of intravenous infusion of Lidocaine and Ketamine during surgery on acute pain after elective laparotomy surgery.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017071935187N1

Enrollment

Registered

2017-11-19

Start date

2013-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute pain after elective laparotomy surgery. Other acute post-procedural pain

Interventions

Intervention 1: In the intervention group, 30 minutes after beginning of surgery, both drugs of Lidocaine and Ketamine will be infused intravenously for patients with the dose of 0.5 mg/kg/hr till end

Treatment - Drugs

In the intervention group, 30 minutes after beginning of surgery, both drugs of Lidocaine and Ketamine will be infused intravenously for patients with the dose of 0.5 mg/kg/hr till end of surgery.

In the control group Lidocaine and Ketamine will not be infused for patients and general anesthesia will just be induced

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ASA I, ASA II, Hb>10, elective laparotomy surgery, consent to participation, no important underlying disease. Exclusion criteria: uncontrolled underlying disease, addiction to alcohol and opioids, sensitivity to opioids, Ketamine or Lidocaine, weight>115kg, height<140cm.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Comparison of acute pain after elective laparotomy surgery. Timepoint: Just after surgery, 6 hrs after surgery, 12 hrs after surgery, 18 hrs after surgery, 24 hrs after surgery. Method of measurement: Visual analog scale.	—

Secondary

Measure	Time frame
Seizure. Timepoint: Any time after beginning of signs & symptoms. Method of measurement: Patient and support person's complaint.;Cardiac arrhythmia. Timepoint: Any time after beginning of signs & symptoms. Method of measurement: Patient and support person's complaint and ECG.;Halucination. Timepoint: Any time after beginning of signs & symptoms. Method of measurement: Patient and support person's complaint.;Nausea & Vomiting. Timepoint: Any time after beginning of signs & symptoms. Method of measurement: Patient and support person's complaint.;Delirium. Timepoint: Any time after beggining of signs and symptoms. Method of measurement: Patient and support person's complaint.;Drug sensitivity. Timepoint: Any time after beginning of signs & symptoms. Method of measurement: Patient and support person's complaint.	—

Measure

Time frame

Seizure. Timepoint: Any time after beginning of signs & symptoms. Method of measurement: Patient and support person's complaint.;Cardiac arrhythmia. Timepoint: Any time after beginning of signs & symptoms. Method of measurement: Patient and support person's complaint and ECG.;Halucination. Timepoint: Any time after beginning of signs & symptoms. Method of measurement: Patient and support person's complaint.;Nausea & Vomiting. Timepoint: Any time after beginning of signs & symptoms. Method of measurement: Patient and support person's complaint.;Delirium. Timepoint: Any time after beggining of signs and symptoms. Method of measurement: Patient and support person's complaint.;Drug sensitivity. Timepoint: Any time after beginning of signs & symptoms. Method of measurement: Patient and support person's complaint.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Farnad Imani

Iran University of Medical Sciences

Farnadimani@yahoo.com+98 21 6651 5758

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026