traumatic brain injury. Intracranial injury
Conditions
Interventions
Intervention 1: Control group: with no intervention. Intervention 2: Intervention group: the intervention group will receive 2.5 mg/kg/day Coenzyme Q10 for 3 months and they will do exercise 60-90 min
Treatment - Drugs
Control group: with no intervention.
Intervention group: the intervention group will receive 2.5 mg/kg/day Coenzyme Q10 for 3 months and they will do exercise 60-90 minutes, three times a week for 12 weeks.
Sponsors
Vice Chancellor for research of Ilam University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: History of Traumatic Brain Injury 6 months ago; 18-65 years old; Stable clinical situation; Having a medical certificate proving participants’ ability to do exercise test; Commitment to complete the study; Ability to understand speech commands to complete study and ability to cycling to do exercise. Exclusion criteria: Severe behavioral, physical and cognitive status preventing completing the study; chronic and systemic disease(cardiovascular, pulmonary...); Failure to cooperate until the end of the study; smoking and Drug addiction.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-6. Timepoint: before intervention and 6th week and 12th week after begining of intervention. Method of measurement: The IL-6 will be measured by ELISA method and by the bender medsystem kit.;Cardiac function. Timepoint: before intervention and 6th week and 12th week after begining of intervention. Method of measurement: Cardiac function will be tested with Bruce protocol.;Respiratory gasses. Timepoint: before intervention and 6th week and 12th week after begining of intervention. Method of measurement: respiratory gases automaticly will be analyzed using Ultima CardiO2.;Hs-CRP. Timepoint: before intervention and 6th week and 12th week after begining of intervention. Method of measurement: hs-CRP will be measured by ELISA method and by the bender medsystem kit.;Malondialdehyde. Timepoint: before intervention and 6th week and 12th week after begining of intervention. Method of measurement: Levels of malondialdehyde will be measured by the Randox kit.;Total antioxidant capacity. Timepoint: before intervention and 6th week and 12th week after begining of intervention. Method of measurement: total antioxidant capacity will be measured by the Randox kit.;Glutathione peroxidase. Timepoint: before intervention and 6th week and 12th week after begining of intervention. Method of measurement: glutathione peroxidase will be measured by the Randox kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAsghar Rahmani
Ilam University of Medical Sciences
Outcome results
None listed