COVID-19 Disease. COVID-19
Conditions
Interventions
Intervention 1: Intervention group: Patients with COVID-19 admitted to ICU will receive 250 mg methyl prednisolone in addition to their standard treatment for three days. Intervention 2: Control grou
Sponsors
Ardabil University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patient with moderate to severe Covid-19 admitted to ICU PaO2/FiO2 Less than 300 Progression of disease severity and not responding to standard treatment prediction of intubation for next 24 hours or those under mechanical ventilation
Exclusion criteria
Exclusion criteria: ,ncontrolled diabetes mellitus Active GI bleeding history of corticosteroid hypersensitivity sever electrolyte imbalances History of treatment with immune-suppressor agents History of corticosteroid use Positive procalcitonin active bacterial or fungal infection HIV and hepatitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality rate. Timepoint: from including to study to 60 days. Method of measurement: observation.;Blood O2 saturation. Timepoint: before and during the study for 14 days. Method of measurement: pulse Oximeter.;Oxygen therapy need. Timepoint: before and during the study for 14 days. Method of measurement: Clinical. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAfshin Habibzadeh
Ardabil University of Medical Sciences
Outcome results
None listed