Knee osthoarthritis. Osteoarthritis, unspecified site
Conditions
Interventions
Intervention 1: Intervention group: In Duloxetine group, patients will be treated with 30 mg daily which will be increased to 60 mg daily. Intervention 2: Intervention group: In gabapentine group, tre
Sponsors
Ardabil University of Medical Sciences
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: idiopathic knee osteoarthritis Age between 45-75 years ability to walk having pain score of >5 according to VAS and >48 according to WOMAC questionnaire
Exclusion criteria
Exclusion criteria: Other knee disorders Concomitant hip and ankle osteoarthritis Bursitis and perarticular disease radicular pains physiotherapy or intraarticular injection during the past 6 months psychological disease history of knee surgery inflammatory joint disease rheumatoid arthritis fibromyalgia active or recurrent pseudogoat malignancy; systemic diseases including renal of hepatic failure, uncontrolled blood pressure, diabetes mellitus asthma in need of corticosteroids corticosteroid use in less than 5 weeks prior to study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: Before intervention and one and three months after intervention. Method of measurement: Using visual analogue scale (VAS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional status. Timepoint: Before intervention and one and three months after intervention. Method of measurement: using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire.;Quality of life. Timepoint: Before intervention and one and three months after intervention. Method of measurement: Using SF-12 quality of life questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAfshin Habibzadeh
Ardabil University of Medical Sciences
Outcome results
None listed