Evaluating the efficacy of methotrexate in pain severity reduction and improvement of quality of life in patients with moderate to severe knee osteoarthritis

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170716035126N1

Enrollment

100

Registered

2017-12-22

Start date

2017-12-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osthoarthritis.

Interventions

Intervention 1: Both groups will be administered glucoseamine sulfate 1500 mg daily and then in intervention group, methotrexate with the dose of 7.5 mg (3 pills) weekly will be administered and then

Treatment - Drugs

Both groups will be administered glucoseamine sulfate 1500 mg daily and then in intervention group, methotrexate with the dose of 7.5 mg (3 pills) weekly will be administered and then increased to 15

both groups will be administered glucoseamine sulfate 1500 mg daily and in placebo group, placebo will be administered 3 pills weekly.

Eligibility

Sex/Gender

All

Age

45 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Knee osteoarthritis with effusion; age between 45-75 years; ability to walk; having pain score of >5 according to VAS and >48 according to WOMAC questionnaire

Exclusion criteria

Exclusion criteria: Exclusion criteria: Other knee disorders; concomitant hip and ankle osteoarthritis; bursitis and perarticular disease; radicular pains; physiotherapy or intraarticular injection during the past 6 months; psychological disease; history of knee surgery; inflammatory joint disease; rheumatoid arthritis; fibromyalgia; active or recurrent pseudogoat; malignancy; systemic diseases including renal of hepatic failure, uncontrolled blood pressure, diabetes mellitus; asthma in need of corticosteroids; corticosteroid use in less than 5 weeks prior to study

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: before intervention and three and six months after intervention. Method of measurement: using visual analogue scale (VAS).	—

Secondary

Measure	Time frame
Functional status. Timepoint: before intervention and three and six months after intervention. Method of measurement: using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire.;Quality of life. Timepoint: before intervention and three and six months after intervention. Method of measurement: using SF-12 quality of life questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAfshin Habibzadeh

Arabil University of Medical Sciences

afshin.habibzadeh@gmail.com+98 45 3352 2391

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026