A Comparison of nitroglycerine skin patch and sublingual tablets of isosorbide di-nitrate for prevention of preterm labor

A comparison of TNG skin patch and Isosorbide di-nitrate for prevention of preterm labor.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017071535090N1

Enrollment

110

Registered

2017-08-19

Start date

2017-10-04

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

preterm labor. Preterm spontaneous labour with preterm delivery

Interventions

Intervention 1: Control group: In the group of TNG skin patch, first, ten mg TNG skin patch will be attached to the lateral arm and the patient will be evaluated about the process of uterine contracti

Prevention

Control group: In the group of TNG skin patch, first, ten mg TNG skin patch will be attached to the lateral arm and the patient will be evaluated about the process of uterine contractions, for an hour

Intervention group: In the Isosorbide di-nitrate group, we provide the patient Isosorbide dinitrate five mg sublingual tablets, every half an hour (Because the half-life is 45 minutes) and we will con

Eligibility

Sex/Gender

Female

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Healthy pregnant women aged 18-35; live fetus with gestational age of 34-36 weeks; having at least 8 regular uterine contractions in an hour Exclusion criteria: rupture of membranes (ROM) ; onset of active labor phase (4 cm dilatation and more) ; vaginal bleeding or symptoms of placenta abruption, Chorioamnionitis, pyelonephritis, Pulmonary heart disease, Diabetes and pregnancy hypertension ; receiving Tocolytic in the past 24 hours

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Preterm labor. Timepoint: Before intervention and 1 hour after intervention. Method of measurement: By physical examination.	—

Secondary

Measure	Time frame
Blood pressure. Timepoint: Before the intervention, 15 minutes after the intervention, 30 minutes after the intervention, 45 minutes after the intervention, 1 hour after the intervention, and then every 4 hours. Method of measurement: By manometer.;Cervical length. Timepoint: Before intervention and 1 hour after intervention. Method of measurement: By physical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehrnaz Mehrkhu

Lorestsn University Of Medical Sciences. Lorestan, Iran

Mmehrkhu@yahoo.comGhafarzade.m@lums.ac.ir+98 66 3330 0661

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026