Cutaneous leishmaniasis. Cutaneous leishmaniasis
Conditions
Interventions
Intervention 1: Intervention: Applying gentian violet 1% ointment twice daily for 8 weeks besides liquid nitrogen cryospray cryotherapy weekly for 8 weeks. Intervention 2: Control: Only liquid nitrog
Treatment - Drugs
Intervention: Applying gentian violet 1% ointment twice daily for 8 weeks besides liquid nitrogen cryospray cryotherapy weekly for 8 weeks
Control: Only liquid nitrogen cryospray cryotherapy weekly for 8 weeks
Sponsors
Research Council of Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: Clinical diagnosis of cutaneous leishmaniasis; Confirmation of diagnosis by direct smear or Polymerase chain reaction test Exclusion criteria: Pregnancy or Lactation; History of consumption of topical or systemic anti-leishmania medications or cryotherapy in the recent 1 month before enrolling in study; Patients with more than 10 lesions; Patients with lesions lasting more than 4 months; Lesions on the cartilages (Ear or nose)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical cure. Timepoint: 4th and 8th weeks of the study. Method of measurement: complete response defined as more than 75% reduction, partial response defined as 50%–75% reduction, and no response to treatment defined as less than 50% reduction in the size of the lesion compared with baseline. Size is measured by multiplying the longest and shortest diameters of the lesion. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: 8th week of the study. Method of measurement: Asking the patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKasra Behdad
Shiraz University of Medical Sciences
Outcome results
None listed