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oral antibiotic effectiveness in prevention of wound infection in hand laceration

Comparison of effectiveness of oral antibiotic with intravenous antibiotic in prophylaxis of wound infection in patients with hand laceration who come to emergency department

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201707118872N12
Enrollment
764
Registered
2017-07-23
Start date
2017-07-27
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hand laceration. Open wound of wrist and hand part, part unspecified

Interventions

Intervention 1: In intervention group, patients receive oral cephalexin per KG of body weight before procedure and receive normal saline as a placebo then discharged home with oral cephalexin for 48
Treatment - Drugs
In intervention group, patients receive oral cephalexin per KG of body weight before procedure and receive normal saline as a placebo then discharged home with oral cephalexin for 48 hours.
In control group patients receive intravenous cefazolin per KG of body weight before procedure and patients receive an oral placebo similar to cephalexin capsules then discharged home with oral cephal

Sponsors

Tehran University of Medical Sciences -Faculty of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion Criteria: patients consent to participation in the study; patients with class 2 hand laceration whom treated by emergency physicians. Exclusion Criteria: patients with crash laceration; hand laceration accompanied by tendon injury that mandate patient admission; open fractures; bite wound; patient needed to admission to other services; laceration which needed to repair in operating room; allergic history to cephalosporins.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Prevalence of wound infection. Timepoint: 48 hours after wound repair. Method of measurement: observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMorteza Saeedi

Tehran University of Medical Sciences

m_saeedi@tums.ac.ir+98 21 8490 2717

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026