The effect of green tea on the treatment of depression

Effect of green tea consumption in the treatment of mild to moderate depression in HIV patients. A randomized, double-blind, controlled clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017071128308N2

Enrollment

Registered

2017-10-14

Start date

2017-11-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV. Unspecified human immunodeficiency virus [HIV] disease

Interventions

Intervention 1: A green tea capsule containing 400 mg of green tea polyphenols (GTP) every 12 hours for 12 weeks. Intervention 2: A placebo capsule every 12 hours for 12 weeks.

Treatment - Drugs

Placebo

A green tea capsule containing 400 mg of green tea polyphenols (GTP) every 12 hours for 12 weeks

A placebo capsule every 12 hours for 12 weeks

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria : confirmation of HIV infection based on Western blot test; receiving highly active antiretrovirals; diagnosing mild to moderate of depression based on DSM IV criteria (Diagnostic and Statistical Manual of mental disorders) and have a Hamilton test (17 items) score of under 20; satisfaction for research; lack of other psychiatric and cognitive diseases (including AIDS-induced dementia). Exclusion criteria: opportunistic infection 90 days before entering the study; severe depression, and a tendency to suicide based on the Hamilton suicide rate, =2; have cancer and pregnancy or delivery in three months ago, or breastfeeding; alcohol dependency; people with malabsorption disorder such as Crohn's disease or chronic pancreatitis; the intake of proton pump inhibitor or H2 blocker; the inability to refrain from drinking tea / tea products (including herbal, caffeine free, caffeine free, Apple juice, chocolate, bean, cherry, juice containing apple, cherry, or plum, food supplements, and herbs for 1 week before baseline evaluation and during the study period.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Depression. Timepoint: Before intervention, 6 weeks after the intervention and 12 weeks after intervention. Method of measurement: Hamilton Standard Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Ali Asadollahi Amin

Tehran University of Medical Science

amiyaneh@gmail.com+98 21 6119 2811

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026