Postoperative pain. acute pain
Conditions
Interventions
Intervention 1: The first group will receive 15 mg ropivacaine and 5 µg dexmedetomidine at a volume of 2 ml intrathecally. Intervention 2: The second group will receive 15 mg ropivacaine and 10 µg dex
Treatment - Drugs
Placebo
The first group will receive 15 mg ropivacaine and 5 µg dexmedetomidine at a volume of 2 ml intrathecally.
The second group will receive 15 mg ropivacaine and 10 µg dexmedetomidine at a volume of 2 ml intrathecally.
The third or control group will receive 15 mg ropivacaine and distilled water at a volume of 2 ml intrathecally.
Sponsors
Arak University of Medical Sciences,Vice chancellor for research
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:Candidate for lower limb orthopedic surgery under spinal anesthesia; Age between 18 to 60 years old; ASA class I and II. Exclusion criteria: Use of beta blockers, alpha-2 agonist and calcium channel blochers; Cardiovascular disease; Pregnancy; Coagulopathy; Local infection in the patient's caudal region; Allergy to dexmedetomidine or ropivacaine; History of psychiatric disorders; central or peripheral neuropathy
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain. Timepoint: at 1, 2, 4, 6 and 12 hours after admission to recovery. Method of measurement: Visual analogue scale.;Mean arterial pressure. Timepoint: Every 15 min until the end of surgery. Method of measurement: sphygmomanometer.;Heart rate. Timepoint: Every 15 min until the end of surgery. Method of measurement: Cardiac monitoring. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Hesameddin Modir
Arak University of Medical Sciences
Outcome results
None listed