Effect of rTMS on HSP

Effect of repetitive trans-cranial magnetic stimulation (rTMS) of lower limb motor cortex on Lower extremity spasticity in patients with hereditary spastic paraplegia (HSP): A randomized sham-controlled double-blind study

Status

Active, not recruiting

Phases

Phase 3

Study type

Observational

Source

IRCT

Registry ID

IRCT20170703034879N2

Enrollment

Registered

2020-09-15

Start date

2017-06-22

Completion date

Unknown

Last updated

2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hereditary spastic paraplegia. Hereditary spastic paraplegia

Interventions

Intervention 1: Intervention group: 5 sessions of 5 Hz rTMS on 5 consecutive days. each session comprised of 5 trains of 60 second duration and 2 minute inter train interval. Intervention 2: Control g

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Diagnosis based on Fink's Criteria Signed written informed consent

Exclusion criteria

Exclusion criteria: History of Seizure Uncontrolled hypertension Cochlear implant Cardiac Pacemaker Foreign body in patient's body

Design outcomes

Primary

Measure	Time frame
Improvement of lower limb spasticity based on modified Ashworth scale. Timepoint: Before intervention, upon completion of 5 sessions of rTMS, 1 moth after intervention. Method of measurement: Modified Ashworth Scale (MAS).	—

Secondary

Measure	Time frame
Change in patients' mobility based on 10-meter walking test. Timepoint: Before intervention, upon completion of 5 sessions of rTMS, 1 month after intervention. Method of measurement: 10-meter Walking test.;Change in motor function of lower limb. Timepoint: Before intervention, upon completion of 5 sessions of rTMS, 1 month after intervention. Method of measurement: Fugl-Meyer Assessment of lower limb (FMA-LE).;Quality of Life. Timepoint: Before intervention, upon completion of 5 sessions of rTMS, 1 month after intervention. Method of measurement: Short form survey 36 (SF-36).	—

Measure

Time frame

Change in patients' mobility based on 10-meter walking test. Timepoint: Before intervention, upon completion of 5 sessions of rTMS, 1 month after intervention. Method of measurement: 10-meter Walking test.;Change in motor function of lower limb. Timepoint: Before intervention, upon completion of 5 sessions of rTMS, 1 month after intervention. Method of measurement: Fugl-Meyer Assessment of lower limb (FMA-LE).;Quality of Life. Timepoint: Before intervention, upon completion of 5 sessions of rTMS, 1 month after intervention. Method of measurement: Short form survey 36 (SF-36).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Siamak Abdi

Tehran University of Medical Sciences

Siamak.Abdi@yahoo.com+98 21 8490 2224

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026