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Tacrolimus in improving clinical symptoms patients with acute asthma attack

The effect of Tacrolimus on improving clinical symptoms, FEV1 and PEFR in patients with acute asthma attack ; Randomized clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2017063015446N11
Enrollment
80
Registered
2017-07-25
Start date
2017-08-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

asthma. Asthma

Interventions

Intervention 1: The intervention group will receive 0.5 mg ipratropium nubulized (repeated up to 3 doses in every 20 minutes) , 5 mg Albuterol inhalation and Prednisolon at the beginning (zero time po
Treatment - Drugs
The intervention group will receive 0.5 mg ipratropium nubulized (repeated up to 3 doses in every 20 minutes) , 5 mg Albuterol inhalation and Prednisolon at the beginning (zero time point). Also, 2 mg
The control group will receive 0.5 mg nebulized ipratropium (repeated up to 3 doses in every 20 minutes) , 5 mg Albuterol inhalation and Prednisolon at the beginning (zero time point).

Sponsors

Ahvaz Jundishapur University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: the age between 18 and 65 years; patients with shortness of breath; cases with a history of asthma that correlate with their clinical and paraclinical parameters Exclusion criteria: The patients with tacrolimus allergy; HCO-60 (polyoxyl 60 hydrogenated castor oil); Hyperpigmentation scars, diabetes mellitus; renal failure; heart failure; electrolyte disorders; uncontrolled blood pressure; neurologic disorders; lymphoma and other malignancies; pregnancy and breast feeding

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
PEFR. Timepoint: 0,30,60,120 and 150 minutes after treatment. Method of measurement: spirometry.;FEV1. Timepoint: 0,30,60,120 and 150 minutes after treatment. Method of measurement: spirometry.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHasan Motamed

Ahvaz Jundishapur University of Medical Sciences

mtdhsn@gmail.com+98 61 3374 3009

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026