Effect of traditional medicines of Rheum Palmatum versus Paeonia Officinalis on primary dysmenorrhea

Comparison of traditional medicines of Rheum Palmatum versus Paeonia Officinalis and Mefenamic acid on primary dysmenorrhea : a randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017062834784N1

Enrollment

105

Registered

2017-07-07

Start date

2017-07-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary dysmenorrhea. Menstruation painful

Interventions

Intervention 1: A capsule of 500 mg of whole root powder of Rheum palmatum is taken from the day before the menstruation up to five days later every 8 hours and, if the symptoms resolve,you could cut

Treatment - Drugs

Placebo

A capsule of 500 mg of whole root powder of Rheum palmatum is taken from the day before the menstruation up to five days later every 8 hours and, if the symptoms resolve,you could cut it off.

A capsule of 500 mg of whole root powder of paeonia officinalis is taken from the day before the menstruation up to five days later every 8 hours and, if the symptoms resolve,you could cut it off.

A capsule of 500 mg of powder of starch is taken from the day before the menstruation up to five days later every 8 hours for the first cycle.

A capsule of 250 mg of mefenamic acid is taken from the day before the menstruation up to five days later every 8 hours and, if the symptoms resolve,you could cut it off.

Eligibility

Sex/Gender

Female

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 18_35years old;Regular menstruation;Severity of pain moderate to severe Exclusion criteria: Pregnancy;Uterine infections;Irregular mense;Allergy to drug;Chronic disease;Acute systemic disease;Pelvic inflammation disease;Tumor and fibrom;Pelvic and abdoman surgery;Stress trigger ;Constipation and hemorrhoid;Psychological disease

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Duration of mense. Timepoint: Monthly. Method of measurement: Hours.;Severity of pain. Timepoint: Monthly. Method of measurement: VAS and VMSS.;Quality of life. Timepoint: Monthly. Method of measurement: questionnaire.;Volume of menstruation. Timepoint: Monthly. Method of measurement: Higham chart.	—

Secondary

Measure	Time frame
To determine the potential adverse events resulting from treatment process in patients in the intervention groups. Timepoint: During the study. Method of measurement: questionnaire-Observation-reportage.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr mohammad bagher fazljou

School of Traditional Medicine, Tabriz University of Medical Sciences

dr.fazljou@yahoo.com+98 41 3337 9529

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026