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Study the effect of co-administration of Orange juice with phenobarbital on its serum level

Study the effect of co-administration of an acid juice (Orange juice) with phenobarbital on its serum level in pediatric with seizure

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2017062519240N3
Enrollment
40
Registered
2017-10-21
Start date
2017-09-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

seizure. seizure ,Epilepsy

Interventions

Intervention 1: Intervention group: Phenobarbital with a dose of 2.5 milligram / kilogram body weight orally with orange juice. Intervention 2: Control group: Phenobarbital with a dose of 2.5 milligra
Treatment - Drugs
Intervention group: Phenobarbital with a dose of 2.5 milligram / kilogram body weight orally with orange juice
Control group: Phenobarbital with a dose of 2.5 milligram / kilogram body weight orally with normal water

Sponsors

Deputy of Research of Sabzevar University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 20 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Children with seizures without fever who have had seizures for the first time; Children with fever and seizures that have seizures lasting more than 15 minutes; Children with fever and seizures that have recurring seizures within 24 hours; Children with fever and seizures that have a seizure with focal manifestations exclusion criteria: Dissatisfaction with the continuation of the plan at any stage of the plan; A child who has had a history of taking phenobarbital in the past; A child with a history of taking any anticonvulsant medication; The infant with her mother is taking a seizure that takes medicine; Children who are over 10 miligram per kilogram for lack of control of seizures receive an initial dose of intravenously.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Serum levels of phenobarbital. Timepoint: Two hours after the intervention. Method of measurement: HPLC machine based on milligram per deciliter.

Secondary

MeasureTime frame
Tonic Clonic Movement of the Patient. Timepoint: An hour after the intervention. Method of measurement: Direct observation and clinical examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMortezaTavasolizadeh

Sabzevar University of Medical Sciences

Drmorteza20@yahoo.com+98 51 4464 4388

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026