Osteochondral defects.
Conditions
Interventions
Evaluation of the safety and effectiveness of the autologous chondrocytes seeded in bilayered scaffolds based on silk fibroin and collagen in presence of growth factors in the treatment of osteochondr
Treatment - Surgery
Sponsors
Avicenna Research Institute
scientific and technological department of presidential office
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: female or male; within the age range of 18 to 65 years; symptomatic osteochondral lesion of the medial or lateral femoral condyles with ICRS grade 3-4 lesion. Exclusion Criteria: meniscus removal with surgical treatment; knee non corrected instability; diagnosis with metastatic diseases or malignant diseases; pregnancy or breast feeding, history of neurological disease; history of endocrinological disorders such as diabetes; history of pulmonary heart diseases; infectious diseases such as hepatitis B and C, HIV and history of allergic diseases.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Radiological and Clinical Studies. Timepoint: Before intervention and 6 months and 1 year after intervention. Method of measurement: Radiographic images.;MRI studies. Timepoint: Before intervention and 6 months and 1 year after intervention. Method of measurement: MRI results. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain in the surgical area. Timepoint: after intervention. Method of measurement: Based on available evidence. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Somaieh Kazemnejadi
Avicenna Research Institute
Outcome results
None listed