Effect of BMP2 versus MTA as a medicament in pulpotomy of primary molars

A comparative study of clinical and radiographic success rates of BMP2 and MTA in pulpotomy of primary molars in 3 to 6 year old children

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017062434726N1

Enrollment

Registered

2017-08-31

Start date

2017-05-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

reversible pulpitis. reversible pulpitis

Interventions

Intervention 1: Intervention group: ?After pulpotomy treatment, 1 microgram recombinant human bone morphogenetic protein 2 (rhBMP2) is placed in pulp chamber. Intervention 2: group2: After pulpotomy

Treatment - Other

Intervention group: ?After pulpotomy treatment, 1 microgram recombinant human bone morphogenetic protein 2 (rhBMP2) is placed in pulp chamber.

group2: After pulpotomy treatment, MTA paste is placed in pulp chamber as a standard pulpotomy medicament.

Eligibility

Sex/Gender

All

Age

3 Years to 6 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Exposed vital tooth without signs and symptoms; Teeth with no clinical or radiographic evidence of pulp degeneration; The possibility of proper restoration of the tooth. Exclusion criteria: Teeth with signs and symptoms; Clinical or radiographic evidence of pulp degeneration; physiologic mobility; Evidence of any pathologial root resorption.

Exclusion criteria

Exclusion criteria:

Design outcomes

Secondary

Measure	Time frame
Internal resorption. Timepoint: before intervention, 3months, 6months, 9months and 12months after intervention. Method of measurement: radigraphic examination.;External resorption. Timepoint: before intervention, 3months, 6months, 9months and 12months after intervention. Method of measurement: radigraphic examination.;PDL widening. Timepoint: before intervention, 3months, 6months, 9months and 12months after intervention. Method of measurement: radigraphic examination.;Radiolucency. Timepoint: before intervention, 3months, 6months, 9months and 12months after intervention. Method of measurement: radigraphic examination.	—

Measure

Time frame

Internal resorption. Timepoint: before intervention, 3months, 6months, 9months and 12months after intervention. Method of measurement: radigraphic examination.;External resorption. Timepoint: before intervention, 3months, 6months, 9months and 12months after intervention. Method of measurement: radigraphic examination.;PDL widening. Timepoint: before intervention, 3months, 6months, 9months and 12months after intervention. Method of measurement: radigraphic examination.;Radiolucency. Timepoint: before intervention, 3months, 6months, 9months and 12months after intervention. Method of measurement: radigraphic examination.

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Primary

Measure	Time frame
Pain. Timepoint: before intervention, 3 months, 6months, 9months and 12 months after intervention. Method of measurement: clinical examination.;Sensitive to percussion. Timepoint: before intervention, 3 months, 6months, 9months and 12 months after intervention. Method of measurement: clinical examination.;Swelling. Timepoint: before intervention, 3 months, 6months, 9months and 12 months after intervention. Method of measurement: clinical examination.;Sinus tract. Timepoint: before intervention, 3 months, 6months, 9months and 12 months after intervention. Method of measurement: clinical examination.;Pathologic mobility. Timepoint: before intervention, 3 months, 6months, 9months and 12 months after intervention. Method of measurement: clinical examination.	—

Measure

Time frame

Pain. Timepoint: before intervention, 3 months, 6months, 9months and 12 months after intervention. Method of measurement: clinical examination.;Sensitive to percussion. Timepoint: before intervention, 3 months, 6months, 9months and 12 months after intervention. Method of measurement: clinical examination.;Swelling. Timepoint: before intervention, 3 months, 6months, 9months and 12 months after intervention. Method of measurement: clinical examination.;Sinus tract. Timepoint: before intervention, 3 months, 6months, 9months and 12 months after intervention. Method of measurement: clinical examination.;Pathologic mobility. Timepoint: before intervention, 3 months, 6months, 9months and 12 months after intervention. Method of measurement: clinical examination.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Sanaz Ziaei

Esfahan University of Medical Sciences

sanaz20_2005@yahoo.com+98 31 3792 5591

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026