The effect of memantine on the pain relief after orthopedic surgery

Comparing the oral use of Memantine with Dextromethorphan and Placebo to reduce Pain after Orthopedic Surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017062413364N4

Enrollment

180

Registered

2017-07-07

Start date

2015-04-04

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute pain. Acute pain

Interventions

Intervention 1: Group (M) receives 30 mg oral Memantine,about two and a half hours before the start of operation. Intervention 2: group (D) receives 45 mg Dextromethorphan, about two and a half hours

Prevention

Group (M) receives 30 mg oral Memantine,about two and a half hours before the start of operation

group (D) receives 45 mg Dextromethorphan, about two and a half hours before the start of operation

group (P) receives placebo, about two and a half hours before the start of operation

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:patients undergoing elective orthopedic surgery of the lower limbs (calf fracture); aged 18-65 years;physical health status of ASA 1 or 2 Exclusion criteria:ASA physical health status of 3 or 4; diseases of the respiratory system, heart, brain and endocrine glands;any opioid consumption in one week prior to surgery;sensitivity to opioid used in the study;a history of mental illness;MAOIs or SSRIs consumption during 4 weeks before the surgery; pregnancy;history of stroke;type 1 and 2 diabetes mellitus.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: 6, 12, 24, 36 and 48 hours after the surgery. Method of measurement: visual analog score.	—

Secondary

Measure	Time frame
Sedation scores. Timepoint: 6, 12, 24, 36 and 48 hours after the surgery. Method of measurement: 0 for restless, 1 for quiet, 2 for sleepy, 3 for confused but with respond to verbal commands, 4 for no response to verbal commands, and 5 for no response to painful stimulus.;Nausea and vomiting. Timepoint: 6, 12, 24, 36 and 48 hours after the surgery. Method of measurement: 1 for mild nausea without the need for medication, 2 for nausea needing medication, 3 for nausea and lack of response to anti-nausea drugs.;Patient satisfaction. Timepoint: At the end of 48 hours post operation. Method of measurement: 0 for absolutely no pain, 1 for sometimes moderate pain, 2 for always moderate pain, 3 for sometimes severe pain, 4 for always moderate pain and sometimes severe pain, and 5 for always severe pain.	—

Measure

Time frame

Sedation scores. Timepoint: 6, 12, 24, 36 and 48 hours after the surgery. Method of measurement: 0 for restless, 1 for quiet, 2 for sleepy, 3 for confused but with respond to verbal commands, 4 for no response to verbal commands, and 5 for no response to painful stimulus.;Nausea and vomiting. Timepoint: 6, 12, 24, 36 and 48 hours after the surgery. Method of measurement: 1 for mild nausea without the need for medication, 2 for nausea needing medication, 3 for nausea and lack of response to anti-nausea drugs.;Patient satisfaction. Timepoint: At the end of 48 hours post operation. Method of measurement: 0 for absolutely no pain, 1 for sometimes moderate pain, 2 for always moderate pain, 3 for sometimes severe pain, 4 for always moderate pain and sometimes severe pain, and 5 for always severe pain.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehrdad Taheri

Shahid Beheshti University of Medical

taheri.1352@yahoo.com+98 217756784000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026