Chronic and Episodic Migraine. Migraine
Conditions
Interventions
Intervention 1: Synbiotic Group:
Of 100 migraine patients, 25 subjects with chronic migraine and 25 subjects with episodic migraine will receive 2 capsules of protexin synbiotic supplement daily for 8
Treatment - Drugs
Placebo
Synbiotic Group:
Of 100 migraine patients, 25 subjects with chronic migraine and 25 subjects with episodic migraine will receive 2 capsules of protexin synbiotic supplement daily for 8 weeks. The sup
Control Group:
Of 100 migraine patients, 25 subjects with chronic migraine and 25 subjects with episodic migraine will receive 2 capsules of placebo with the same smell and taste as protexin supplem
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Willingness to participate in the study; Age range between 18 to 60 years old; Diagnosis of chronic and episodic migraine headache according to the International Classification of Headache Disorders, 3rd edition (ICHD3 beta) criteria; Passing more than three months from migraine diagnosis; Migraine headache with more than 15 attacks per month for chronic migraine patients; Migraine headache with 3-15 attacks per month for episodic migraine patients; Not taking a synbiotic supplement or foods which fortified by Synbiotic two months before entering the study. Exclusion criteria: Taking anti-psychotic drugs and/or antibiotic drugs during 2 months before the study; Pregnancy (or having a planned pregnancy); Lactation; Unwillingness to participate or continue the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of migraine headache. Timepoint: before and two months after the intervention. Method of measurement: headache diary and examination by neurologist.;Frequency of migraine attacks per month. Timepoint: before and two months after the intervention. Method of measurement: headache diary and examination by neurologist.;Duration of migraine headache. Timepoint: before and two months after the intervention. Method of measurement: headache diary and examination by neurologist. | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of abortive drugs taken. Timepoint: before and two months after the intervention. Method of measurement: questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Soodeh Razeghi Jahromi
School of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research In
Outcome results
None listed