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comprarison both type chemothrapy

Comparison of modify Doxotel, Cisplatin, 5fluoracil versus Eloxatin chemotherapy regimens in terms of overall survival and progression free survival in patients with advanced gastric and gastroesophageal junction cancer

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2017062134670N1
Enrollment
180
Registered
2017-08-07
Start date
2015-03-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neoplasm. Malignant neoplasms of digestive organ

Interventions

Intervention 1: In one group, use chemotherapy to Eloxatin with 130 mg/m2 intravenous for two hours and Epirubicin 50 mg/m2 bolus intravenous and Capecitabine 625 mg/m2 for two days for eight cycles.
Treatment - Drugs
In one group, use chemotherapy to Eloxatin with 130 mg/m2 intravenous for two hours and Epirubicin 50 mg/m2 bolus intravenous and Capecitabine 625 mg/m2 for two days for eight cycles
Two groups use chemotherapy with Docetaxel 40mg/m2 intravenous infusion and Cisplatin 40 mg/m2 intravenous infusion and 5-fluorauacil 400 mg/m2 intravenous infusion for four days for eight cycles

Sponsors

Vice chancellor for research , Jondy Shapor University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion major eligibility criteria : female and male ;18 until 65 years; functional class; critria for histology of adenocarcinoma gastric and Gastroesophageal junction; not finding for family geoghrafic psyicatric state with effect for ejucation; exclusion major eligibility criteria : peripheral nouropathy ; Cerebrovascular disease ;Myocardial infarction ; Pulmonary thrombo emboly ; unstable angina ; uncontrol infection ; pregnancy and lactation ; previce medication for adenocarcinoma; lower limd artritic ; thyapy with phenytoin; known malignancy;

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Progression free survival. Timepoint: To month. Method of measurement: From start chemotherapy to last follow up or recovery.

Secondary

MeasureTime frame
Overall survival. Timepoint: To month. Method of measurement: From start chemotherapy to last follow up or partial recovery.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactPhysician Ahmad Ahmadzadeh

Master of Jondy Shapor University of Medical Sciences

Ahmad. Ahmadzadeh@gmail.com+98 61 3374 3013

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026