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The effect of Ondansetron in combination with Apotel in pain control

The Comparison of the effect of Ondansetron and Apotel on postoperative pain control in patients with upper limb fracture undergoing general anesthesia

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2017062133566N1
Enrollment
50
Registered
2017-08-19
Start date
2017-08-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with upper limb fractures..

Interventions

Intervention 1: Intervention group: the pain pump will contain 2 grams of Apotel and 8 milligrams of Ondansetron, which will be diluted with 100 cc normal saline 0.9 % and will be delivered at the rat
Treatment - Drugs
Control group:the pain pump will contain 2 grams of Apotel, which will be diluted with 100 cc normal saline 0.9 % and will be delivered at the rate of 4 cc / hr.
Intervention group: the pain pump will contain 2 grams of Apotel and 8 milligrams of Ondansetron, which will be diluted with 100 cc normal saline 0.9 % and will be delivered at the rate of 4 cc / hr.

Sponsors

Vice chancellor for research, Golestan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 90 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ASA Class 1; Upper limb fracture; Patients who undergo anesthesia with propofol as an anesthetic inducer; Satisfied to participate in the study; being at the age of 15 and older. Exclusion criteria: ASA grade 3 and 4; uncontrolled diabetes; history of ischemic heart disease (IHD); history of stroke; malignancy; psychiatric problems; Pregnancy; surgery duration greater than 120 minutes; history of substance abuse or drug abuse; Alcohol consumption; history of liver problems; history of Apotel (acetaminophen) sensitivity; history of nausea and vomiting after previous surgical procedure; Patients with long Q-T intervals.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: 24 hours and 48 hours after recovery. Method of measurement: Visual Analogue Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mohammadhosein Taziki

Golestan University of Medical Sciences

dr.taziki@goums.ac.ir+98 17 3242 1660

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026