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Investigating the effect of preoperative nicorandil drug on myocardial injury after open heart surgery

Investigating the effect of preoperative nicorandil drug on myocardial injury after open heart surgery in Shahid Dr. Chamran Medical Training Center- Isfahan

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20170620034666N6
Enrollment
70
Registered
2024-01-05
Start date
2023-06-07
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart surgery. Mechanical complication of other vascular grafts

Interventions

Intervention 1: Intervention group: Intervention group: nicorandil drug, dose 10 mg, 3 times, in the morning of the operation day (one dose at 8 am) and the day before the operation (two doses at 8 am

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 75 Years

Inclusion criteria

Inclusion criteria: Coronary artery bypass surgery for patients. Their age range is 30 to 75 years cardiac output is between 45 and 60%.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Cardiac troponin levels. Timepoint: Measurement of troponin levels before the operation and 8 and 24 hours after the operation. Method of measurement: Troponin kit.

Secondary

MeasureTime frame
Need for inotropic drugs. Timepoint: After the operation. Method of measurement: dose.;Length of stay in Heart ICU. Timepoint: After the operation. Method of measurement: Hours.;When mechanical ventilation is needed. Timepoint: After the operation. Method of measurement: Hours.;The need to use an intra-aortic balloon pump. Timepoint: After the operation. Method of measurement: Yes/No.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehran Shahzamani

Esfahan University of Medical Sciences

m.shahzamani@med.mui.ac.ir+98 31 3260 0961

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026