Comparison of the effect of methylprednisolone and dexamethasone in prime solution

Comparative study of clinical outcomes of methylprednisolone and dexamethasone in prime solution during cardiopulmonary pump after coronary artery bypass grafting in patients candidate for bypass surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170620034666N2

Enrollment

Registered

2019-09-24

Start date

2019-07-31

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery bypass graft surgery. Mechanical complication of coronary artery bypass graft and biological heart valve graft

Interventions

Intervention 1: Intervention group 1: In dexamethasone group, 8 mg dexamethasone (Iran Hormone Company) is used in the prime solution. In the first 24 hours after surgery, the patient receives 8 mg de

Eligibility

Sex/Gender

All

Age

40 Years to 60 Years

Inclusion criteria

Inclusion criteria: All patients undergoing coronary artery bypass grafting surgery Consent to participate in the study

Exclusion criteria

Exclusion criteria: History of valve surgery Less than 40 years old and over than 60 years old Ejection fraction less than 40%

Design outcomes

Primary

Measure	Time frame
Bleeding. Timepoint: After surgery. Method of measurement: Observation.;Hospitalization days. Timepoint: At the time of discharge. Method of measurement: Based on the day.;Inotrope intake. Timepoint: After the surgery. Method of measurement: Based on the recorded checklist.;Duration of mechanical ventialtion. Timepoint: At the time of discharge. Method of measurement: Based on the hour.;Arrhythmia. Timepoint: Continuously until discharge from cardiac intensive care unit. Method of measurement: Electrocardiogram.	—

Measure

Time frame

Bleeding. Timepoint: After surgery. Method of measurement: Observation.;Hospitalization days. Timepoint: At the time of discharge. Method of measurement: Based on the day.;Inotrope intake. Timepoint: After the surgery. Method of measurement: Based on the recorded checklist.;Duration of mechanical ventialtion. Timepoint: At the time of discharge. Method of measurement: Based on the hour.;Arrhythmia. Timepoint: Continuously until discharge from cardiac intensive care unit. Method of measurement: Electrocardiogram.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehran Shahzamani

Esfahan University of Medical Sciences

m.shahzamani@med.mui.ac.ir+98 31 3670 1227

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 16, 2026