The effect of probiotic supplementation on cognitive function and inflammatory markers in patients with early and late phases of Alzheimer's disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017061534549N1

Enrollment

Registered

2017-10-24

Start date

2017-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer,s disease.

Interventions

Intervention 1: Intervention group: Probiotics -Including : Bididobacterium lactis,Bifidobacterium bifidum,Bifidobacterium longum And Lactobacillus plantarum,Lactobacillus fermentum, Lactobacillus a

Treatment - Drugs

Control group: Maltodextrin -Including orligosacharide with alpha- 1,4 and alpha 1,6 bonds Capsulated maltodextrine - each person receiving one capsule/day – -duration

Intervention group: Probiotics -Including : Bididobacterium lactis,Bifidobacterium bifidum,Bifidobacterium longum And Lactobacillus plantarum,Lactobacillus fermentum, Lactobacillus acidophilus ?

Eligibility

Sex/Gender

All

Age

65 Years to 90 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: The patients will be categorized based on the Mini Mental State Examination (MMSE) test, age (65-90) and sex. Exclusion criteria: any disease other than the cognitive problems in the patients such as metabolic disorders

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Memory (based on Mini Mental State Examination test). Timepoint: before and after 4 months of intervantion. Method of measurement: Interview.	—

Secondary

Measure	Time frame
Serum inflammatory factors. Timepoint: Before and 4 months after intervention. Method of measurement: measurments in serum through Elisa kits.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mahmoud Salami

Kashan University of Medical Sciences

salami-m@kaums.ac.ir+98 31 5562 1157

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026