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Effect of autologous platelet-rich plasma on improving pregnancy outcomes in repeated implantation failure :A randomized controlled trial

Effect of autologous platelet-rich plasma on improving pregnancy outcomes in repeated implantation failure: A randomized controlled trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2017061434525N1
Enrollment
118
Registered
2017-10-07
Start date
2017-05-01
Completion date
Unknown
Last updated
2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Complications of attempted introduction of embryo in embryo transfer

Interventions

Intervention 1: intervention group: Injection of autologous platelet-rich plasma into the uterine cavity before embryos are transferred into the uterine cavity. Intervention 2: Control group: the stan

Sponsors

Iranian academic center for education culture and research
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Women of childbearing age (18-45 yrs) A history of RIF (repeated implantation failure) during ART(Assisted reproductive technology ) treatments

Exclusion criteria

Exclusion criteria: pregnancy, Diagnosed cancers, Hemoglobin less than 11 gr per deciliter, Patelets less than 150,000/ cc, Use of anticoagulants, Use of Non-steroidal anti-inflammatory drugs up to 10 days before the procedure, Any physical or mental illness that affects the patient's immunity and admission and disrupts the process of project implementation and patient follow-up.

Design outcomes

Primary

MeasureTime frame
Positive pregnancy report with ßHCG laboratory confirmed. Timepoint: 4 weeks after intervention. Method of measurement: Measurement of ßHCG hormone (mg / dl) by the Laboratory.;Check the pregnancy sac ,. Timepoint: 3 weeks after the check of positive HCG. Method of measurement: sonography.;Check the fetus heart rate. Timepoint: 7 weeks after intervention. Method of measurement: sonography.

Secondary

MeasureTime frame
Ongoing Intrauterine pregnancy diagnosis. Timepoint: During pregnancy. Method of measurement: sonography.;Ectopic pregnancy. Timepoint: During pregnancy. Method of measurement: sonography.;Abortion. Timepoint: During pregnancy. Method of measurement: sonography.;Live birth. Timepoint: end of pregnancy. Method of measurement: child birth.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Jafarzadeh

ACECR

sjafarzadeh@gmail.com+98 41 3329 5730

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026