Condition 1: bloodstream infections. Condition 2: Ventilator Associated Pneumonia.
Conditions
Interventions
Intervention 1: Intervention group: Patients receive a loading dose of 150,000 IU/Kg.The loading dose is followed by 50,000 IU every 8 hours. Clinical, microbiological and laboratory findings are coll
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Months to 18 Years
Inclusion criteria
Inclusion criteria: Colistin receiving for at least four days Normal baseline renal status before administration of Colistin Children from 1 month to 18 years Children with a positive blood culture or VAP Gram negative culture which is only susceptible to Colistin
Exclusion criteria
Exclusion criteria: Parents Dissatisfaction Receiving Nebulized form of Colistin for VAP Receiving antibiotics effective on gram negative micro organisms other than Colistin and Meropenem
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical response. Timepoint: at the beginning of the study (before starting the intervention) and 72 hours after the start of treatment. Method of measurement: Laboratory data.;Microbiological response. Timepoint: at the beginning of the study (before starting the intervention) and 72 hours after the start of treatment. Method of measurement: Microbial culture. | — |
Secondary
| Measure | Time frame |
|---|---|
| The prevalence and severity of Nephrotoxicity. Timepoint: 72hrs after starting Colistin. Method of measurement: Laboratory data; Measurement of Urine Volume.;The prevalence of Neurotoxicity. Timepoint: 72hrs after starting Colistin. Method of measurement: Clinical outcomes.;The prevalence of Colistin resistance. Timepoint: 72hrs after starting Colistin. Method of measurement: Microbial culture. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShiva Fatehi
Tehran University of Medical Sciences
Outcome results
None listed