Generalized convulsive status epileptics.. Other status epilepticus
Conditions
Interventions
Intervention 1: Intervention group: Group A: Levetiracetam 40mg/kg infused in 15 minutes. Intervention 2: Control group: Group B: Phenytoin 20 mg/kg infused in 30minutes.
Sponsors
Children Hospital and institute of Child Health
Eligibility
Sex/Gender
All
Age
1 Years to 14 Years
Inclusion criteria
Inclusion criteria: Male and Female Patients aged one to 14 years. Patients with generalized convulsive status epilepticus, not responding to two doses of diazepam (0.2 mg/kg) given 5 minutes apart. Parents /guardians of children willing to give Written informed consent.
Exclusion criteria
Exclusion criteria: Children received anticonvulsant treatment other than benzodiazepine for the acute management of CSE. Children on assisted ventilation Children with CSE secondary to hypertensive encephalopathy, head injury, chronic kidney or liver disease and electrolyte derangement (hypoglycemia, hypocalcaemia, hypo/hypernatremia, hypomagnesaemia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy: cessation of seizures. Timepoint: within 30 minutes of administration. Method of measurement: Visual Inspection. | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety: • Respiratory depression • Cardiac depression • Hypotension • Central nervous system (CNS) depression. Timepoint: From administration of study drug till the patient under monitoring for acute condition. Method of measurement: Monitoring was done by base line arterial blood gases, electrocardiogram, blood pressure and Glasgow coma scale. | — |
Countries
Pakistan
Contacts
Public ContactDr. Nuzhat Noureen
Children Hospital and institute of Child Health
Outcome results
None listed