Effect of Granisetron & Ondansetron on induced hypotension of spinal anesthesia

Comparison of the Prophylactic Effect Of Intravenous Ondansetron And Granisetron on Hypotension Induced Through Spinal Anesthesia in Cesarean Delivery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017061334519N1

Enrollment

210

Registered

2017-08-14

Start date

2017-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cesarian. Delivery by elective caesarean section

Interventions

Intervention 1: O intervention group: 4mg Ondansetron that diluted with 10cc saline normal is injecting intravenously 5 minutes before spinal anesthesia. Intervention 2: G group intervention: 1mg Gran

Treatment - Drugs

O intervention group: 4mg Ondansetron that diluted with 10cc saline normal is injecting intravenously 5 minutes before spinal anesthesia

G group intervention: 1mg Granisetron that diluted with 10cc saline normal is injecting intravenously 5minutes befor spinal anesthesia

control group: 10cc saline normal is injecting 5minutes befor spinal anesthesia

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Pregnant women aged 18 to 45 with ASA class1,2 for elective cesarean section under spinal anesthesial. Exclusion criteria: coagulopathy; hemodynamic impaired; history of allergy to anesthesia or medication drugs are studied; taking SSRI anti-seizure & anti migraine; patients suffering from hypertensive disorder; any contraindication to spinal anesthesia; spinal anesthesia failure Open in Google Translate

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Hemodynamic condition. Timepoint: befor of intervension then every 3minutes to 20 minutes. Method of measurement: by monitor device.	—

Secondary

Measure	Time frame
Hypotension. Timepoint: befor intervention then every 3minute until 20 minutes. Method of measurement: by the monitor.;Bradicardia. Timepoint: befor intervention then every 3minute until 20 minutes. Method of measurement: by the monitor.;Nausea. Timepoint: when event. Method of measurement: patient complain.;Vomiting. Timepoint: when event. Method of measurement: patient complain.;Chill. Timepoint: when event. Method of measurement: patient complain.	—

Measure

Time frame

Hypotension. Timepoint: befor intervention then every 3minute until 20 minutes. Method of measurement: by the monitor.;Bradicardia. Timepoint: befor intervention then every 3minute until 20 minutes. Method of measurement: by the monitor.;Nausea. Timepoint: when event. Method of measurement: patient complain.;Vomiting. Timepoint: when event. Method of measurement: patient complain.;Chill. Timepoint: when event. Method of measurement: patient complain.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Marzieh Fadaei

Zahedan Medical Science University

m_fadaei1979@yahoo.com+98 54 3329 0475

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026