Effect of omega-3 plus vitamin E supplementation in treatment of patients with Parkinson's

Clinical trial of the effect of omega-3 plus vitamin E supplementation compared with the placebo on levels of gene expression related with glycemic control, lipid and inflammatory factors in patients with Parkinson's

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017061234497N1

Enrollment

Registered

2017-06-20

Start date

2017-04-20

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson disease. Parkinson disease

Interventions

Intervention 1: Control group: Placebo, daily, for 12 weeks orally. Intervention 2: Intervention group: Omega-3 fatty acid plus vitamin E capsule, 1000 mg omega-3 fatty acid plus 400 IU vitamin E, dai

Eligibility

Sex/Gender

All

Age

50 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients with Parkinson's; aged 50 to 80 years.

Exclusion criteria

Exclusion criteria: Subjects who were already taking omega-3 and/or vitamin E Subjects who were taking DDP4 inhibitors, statins and anti-inflammatory drugs Subjects who had depression and had severe psychosis.

Design outcomes

Primary

Measure	Time frame
Tumor necrosis factor alpha. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: PCR.;Interleukin-1. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: PCR.;Interleukin-8. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: PCR.	—

Secondary

Measure	Time frame
Peroxisome proliferator–activated receptor ? (PPAR?). Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: PCR.;Low Density Lipoprotein Receptor (LDLR). Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: PCR.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZatollah Asemi

Kashan University of Medical Sciences

asemi_z@kaums.ac.ir+98 31 5546 3378

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026