Perennial allergic rhinitis. Other allergic rhinitis
Conditions
Interventions
Treatment - Drugs
Intervention 1: In Intervention group synbiotic capsule give once a day for two month with immunotherapy. Intervention 2: In control group placebo capsule give once a day for two month with immunother
Sponsors
Vice chancellor for research, Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria:patients with persistent allergic rhinitis; Mashhad residents and surrounding towns; Have a positive skin test with Aeroallergen; Cooperate in projects Exclusion criteria: A history of autoimmune disease; Systemic corticosteroids or immunosuppressive drugs consumption and effective on immune system; Pregnant Women; Patients with immunodeficiency; Patients with malnutrition; Use Antibiotic during synbiotic consumption
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene expression of FoxP3,TGF-ß,IL-17,IL-10,IL-4,IFN-?. Timepoint: Before intervention, after 2 month, after 6 month. Method of measurement: Real Time-PCR.;Quality of life. Timepoint: Before intervention, after 2 month, after 6 month. Method of measurement: questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Systemic reactions to immunotherapy. Timepoint: At every turn immunotherapy. Method of measurement: Clinical. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSajad Dehnavi
Mashad Universityof Medcal Sciences
Outcome results
None listed