Effects Of Autologus Platelet- Rich Plasma on Pregnancy Rate in Intra Cytoplasmic Sperm Injection (ICSI) cycles in Repeated Implantation Failure Patients.

The Single blind clinical trial of Effects Of Autologus Platelet- Rich Plasma on Pregnancy Rate in ICSI cycles in Repeated Implantation Failure Patients.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017061034422N1

Enrollment

Registered

2017-11-05

Start date

2017-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

INFERTILITY- recurrent implantation failure. Complication associated with artificial fertilization, unspecified

Interventions

Intervention 1: In intervention group, PRP will be done for patient 48 hours before embryo transfer. For PRP, 8.5 cc of peripheral blood will be given and the number of platelet will be checked. Then

Treatment - Other

In intervention group, PRP will be done for patient 48 hours before embryo transfer. For PRP, 8.5 cc of peripheral blood will be given and the number of platelet will be checked. Then the blood will b

In control group, the embryo transfer catheter will be inserted for patient 48 hours before embryo transfer and will be removed without injection of anything.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Patients who have had at least two unsuccessful embryo transfer cycles (fresh or frozen embryo); At least 6 good quality embryos (grade A or B) were transferred in previous cycles; Semen count=10 millions, normal morphology =3% in their husbands' semen analysis Exclusion criteria: Patients with immunologic disorders (abnormality in CD markers, Anti TG, Anti TPO, ds DNA, ANA); Hematologic disorder; Genetic diseases; Uterus disorders; Hb<11 mg/dl and Platelet<150000/mm3; Systemic usage of corticosteroids during 14 days before use of PRP

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Chemical Pregnancy Rate. Timepoint: Two weeks after embryo transfer. Method of measurement: Blood Beta HCG.;Clinical Pregnancy Rate. Timepoint: Six weeks after embryo transfer. Method of measurement: Sonography. If normal fetal heart rate will be seen in sonography.	—

Secondary

Measure	Time frame
Implantation Rate. Timepoint: Six weeks after embryo transfer. Method of measurement: Statistical method by (number of embryos transfer /number of pregnancy sacs in sonography 6 weeks after ET).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSheyda Jouhari

Avicenna Infertility Clinic

s.jouhari@ari.ir; info@avic.ir+98 21 23519

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026