Condition 1: Chronic hepatic failure. Condition 2: Hepatic Encephalopathy. Chronic hepatic failure Encephalopathy in diseases classified elsewhere
Conditions
Interventions
Intervention 1: First Intervention group: consists of 30 patients receiving 1 Comflor Probiotic capsule(450 billion CFU) twice a day and 30 mL of Lactulose 4 times a day for 3 months. Intervention 2:
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients between ages 18 and 80 years Cirrhotic patients who had recovered from an episode of overt hepatic encephalopathy
Exclusion criteria
Exclusion criteria: Patients on probiotic therapy History of alcohol intake during the past 6 weeks Active infection at the time of enrollment in the study Previous transjugular intrahepatic portosystemic shunt or shunt surgery Renal failure Use of psychoactive drugs, such as antidepressants or sedatives Any neurologic diseases, such as Alzheimer’s disease, Parkinson’s disease, and Non hepatic metabolic encephalopathies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood ammonia levels. Timepoint: Immediately before intervention, At the end of the intervention (3 months from baseline). Method of measurement: Pathobiology laboratory.;Psychometric performance. Timepoint: Immediately before intervention, At the end of the intervention (3 months from baseline). Method of measurement: Trail making task A, Trail making task B, Symbol digit modality task.;Recurrence of Hepatic Encephalopathy. Timepoint: At the end of the intervention (3 months from baseline). Method of measurement: Patient medical file. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life. Timepoint: Immediately before intervention, At the end of the intervention (3 months from baseline). Method of measurement: SF36 health survey questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAfshin Gharekhani
Tabriz University of Medical Sciences
Outcome results
None listed