COVID _19. Coronavirus infection, unspecified
Conditions
Interventions
Intervention 1: Intervention group (L-carnitine + standard care): 50 patients with COVID-19 diagnosis will be included in the study according to the inclusion and exclusion criteria, and will receive
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: adults aged 18 years or older Positive PCR test for COVID-19 Patients with moderate to severe disease Signs and Symptoms compatible with COVID-19 disease according to the Iranian Ministry of Health protocol Prior to the fifth day of symptoms onset
Exclusion criteria
Exclusion criteria: Pregnancy Lactation HIV Infection History of taking L-carnitine supplement in the recent Month known immunosuppression condition or any active malignancy Patients with hypothyroidism or hyperthyroidism patients with regular aerobic training (more than 3 times a week with further than 2 hours each time) History of allergy to L-carnitine or its analogues History of or an increased risk for seizure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The length of hospitalization. Timepoint: At the end of study. Method of measurement: Comparing the number of hospitalization days between the intervention group and control group.;Disease severity. Timepoint: Daily. Method of measurement: Disease Severity Checklist in NIH Guidelines.;Mortality. Timepoint: End of study. Method of measurement: Patient file.;Time to improve clinical symptoms. Timepoint: Daily. Method of measurement: Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Ferritin level. Timepoint: At the beginning and end of the study. Method of measurement: Ferritin kit.;Serum LDH (Lactate Dehydrogenase) level. Timepoint: At the beginning and end of the study. Method of measurement: Alkaline phosphatase Assay Kit (DGKC Kit).;Serum D_dimer level. Timepoint: At the beginning and end of the study. Method of measurement: D_dimer ELISA kit.;Serum C_ reactive protein (CRP) level. Timepoint: At the beginning and end of the study. Method of measurement: CRP ELISA Kit.;Oxygen saturation. Timepoint: Daily. Method of measurement: oxymeter.;Require for mechanical ventilation. Timepoint: daily. Method of measurement: observation.;L-carnitine serum level. Timepoint: baseline and end of the study. Method of measurement: ELISA kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAfshin Gharekhani
Tabriz University of Medical Sciences
Outcome results
None listed