Assessing the Efficacy of Intra-articular Injection of High Molecular Weight Hyaluronic Acid on Knee Function of Patients with Tibial Plateau Fracture after Surgical Fixation

Evaluating the Efficacy of Intra-articular Injection of High molecular weight Hyaluronic Acid on the Knee Performance of Patient with Tibial Plateau Fracture after Surgical Intervention

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170608034390N3

Enrollment

Registered

2019-06-13

Start date

2018-05-16

Completion date

Unknown

Last updated

2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tibial Plateau Fracture. Fracture of upper end of tibia

Interventions

Intervention 1: Control group:intra-articular injections of 2 ml Normal Saline in 2, 4 weeks after surgery, under sterile conditions and by an orthopedic specialist. Intervention 2: Intervention group

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Adults (18-65 years) Tibial Plateau Fracture Signing the Informed Consent

Exclusion criteria

Exclusion criteria: Pregnancy & Lactation Diabetes Mellitus Severe osteoarthritis Sever Osteoporesis Non-surgical patients (Active septic disorders of knee joint and tissues around the knee, Coagulopathies, Active rheumatologic disorders, Heart Failure, COPD, ....) Open fractures Failure to perform internal fixation due to extensive tissue damage

Design outcomes

Primary

Measure	Time frame
Pain by Visual Analogue Scale (VAS) score. Timepoint: Starting point, 2 and 22 weeks after first Injection. Method of measurement: Using standard scale for VAS score.	—

Secondary

Measure	Time frame
Range of Motion. Timepoint: Starting point (2 weeks after fixation operation), 2 and 22 weeks after first Injection. Method of measurement: Using goniometer.;Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Score). Timepoint: Starting point, 2 and 22 weeks after first Injection. Method of measurement: Using validated questionnaire of WOMAC Score.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHadi Esmaily

Shahid Beheshti University of Medical Sciences

esmaily_hadi@sbmu.ac.ir+98 21 8887 3704

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026