Knee Osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intra-articular injection into the affected knee joint of a syringe containing 60 mg hyaluronic acid and 90 mg chondroitin sulfate (3 mL), administered in two sessions at a 4-week inte
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients with mild to moderate knee osteoarthritis Sign the written consent form
Exclusion criteria
Exclusion criteria: Corticosteroid injection into the study knee less than 3 months ago History of septic arthritis of the knee; knee ulcer History of surgery or trauma to the knee History of Hypersensitivity reactions or allergy to hyaluronic acid or chondroitin Advanced osteoarthritis Active infections in the tissues around the knee Other inflammatory joint disorders, such as rheumatoid arthritis, psoriatic arthritis, gout, and other related conditions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale (VAS). Timepoint: Before injection, 24 hours after each injection, 3 months after second injection. Method of measurement: Using the Visual Analogue Scale (VAS), a pain rating scale that is recorded by subjective reports. The patient records their pain level from 0 (no pain) to 10 (the most severe pain). | — |
Secondary
| Measure | Time frame |
|---|---|
| WOMAC Questionnaire. Timepoint: Before injection, 24 hours after each injection, 3 months after second injection. Method of measurement: Using the validated WOMAC index which contain 24 items include pain (5 questions about the visual pain with scoring from 0-10), stiffness (2 questions about the difficulty of movement with scoring from 0-8), and physical function (17 questions about the range of motion with scoring from 0-68). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactTayebeh Eslami
Shahid Beheshti University of Medical Sciences
Outcome results
None listed