Patients with Traumatic brain injury. Diffuse traumatic brain injury
Conditions
Interventions
Intervention 1: Intervention group: Aminophylline produced by Sinadaroo Company, Tehran, Iran. Aminophylline administrated with a loading dose of 5 mg/kg (maximum 500 mg) and a maintenance dose based
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with Traumatic Brain Injury undergoing mechanical ventilation for at least 48 hours.
Exclusion criteria
Exclusion criteria: Patients with a history of allergy to theophylline, caffeine or aminophylline Patients with a history of severe asthma or chronic obstructive pulmonary disease Patients treated with theophylline, caffeine or other methylxanthines Users of drugs that increase or decrease theophylline/aminophylline levels (allopurinol (over 600 mg per day), cimetidine, ciprofloxacin, erythromycin, fluvoxamine, pentoxifylline, propranolol, verapamil, carbamazepine, fosphenytoin, phenobarbital, phenytoin, rifampicin and ritanavir)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The need for re-intubation in patients. Timepoint: Patient follow-up points will be during extubation and 7 days after. Method of measurement: Rapid shallow index. | — |
Secondary
| Measure | Time frame |
|---|---|
| Intubation failure rate. Timepoint: Up to 7 days after extubation of the patient. Method of measurement: Need for re-intubation within a week after extubation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHadi Esmaily
Shahid Beheshti University of Medical Sciences
Outcome results
None listed