The effectiveness of Hyaluronic acid/Chondroitin injection on knee performance after surgical fixation.

Evaluating the efficacy of intra-articular injection of high molecular weight hyaluronic acid and Chondroitin on the knee performance of patients with plateau fracture after surgical fixation

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170608034390N13

Enrollment

Registered

2024-05-30

Start date

2024-06-21

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fracture of patella. Fracture of upper end of tibia

Interventions

Intervention 1: Intervention group: injecting a syringe containing 40 mg of hyaluronic acid and 60 mg of chondroitin (3 ml) intra-articularly into the involved knee joint on two occasions with an inte

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Adult patients in the age range of 18 to 65 years with a fracture of the tibial plateau Sign the written consent form

Exclusion criteria

Exclusion criteria: Uncontrolled diabetes Severe Osteoarthritis Severe osteoporosis Open fractures Inability to perform internal fixation due to tissue damage Impossibility of performing internal fixation due to past medical history Infectious diseases in the knee joint or surrounding tissues Patients with active rheumatological disorders Pregnancy Lactation

Design outcomes

Primary

Measure	Time frame
Visual Analogue Scale (VAS) of the pain rating scales. Timepoint: Measuring the severity of pain index 2 weeks after surgery (right before the first injection), 4 weeks after surgery (right before the second injection), and 22weeks after surgery. Method of measurement: VAS (visual analogue scale) Pain scale from 0 to 10.	—

Secondary

Measure	Time frame
ROM (range of motion). Timepoint: Measuring the range of motion index 2 weeks after surgery (right before the first injection), 4 weeks after surgery (right before the second injection), and 22weeks after surgery. Method of measurement: Goniometer.;WOMAC (Western Ontario and McMaster Universities Arthritis). Timepoint: Measuring the WOMAC index 2 weeks after surgery (right before the first injection), 4 weeks after surgery (right before the second injection), and 22weeks after surgery. Method of measurement: Using the validated WOMAC index which contain 24 items include pain (5 questions about the visual pain with scoring from 0-10), stiffness (2 questions about the difficulty of movement with scoring from 0-8), and physical function (17 questions about the range of motion with scoring from 0-68).	—

Measure

Time frame

ROM (range of motion). Timepoint: Measuring the range of motion index 2 weeks after surgery (right before the first injection), 4 weeks after surgery (right before the second injection), and 22weeks after surgery. Method of measurement: Goniometer.;WOMAC (Western Ontario and McMaster Universities Arthritis). Timepoint: Measuring the WOMAC index 2 weeks after surgery (right before the first injection), 4 weeks after surgery (right before the second injection), and 22weeks after surgery. Method of measurement: Using the validated WOMAC index which contain 24 items include pain (5 questions about the visual pain with scoring from 0-10), stiffness (2 questions about the difficulty of movement with scoring from 0-8), and physical function (17 questions about the range of motion with scoring from 0-68).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactParand rostamian

Shahid Beheshti University of Medical Sciences

parandviolet9@gmail.com+98 21 8820 0118

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026