The effect of herbal and dark chocolate on blood pressure, oxidative stress and lipid parameters in hypertensive patients consuming losartan in Sabzevar

comparison between a herbal chocolate and dark Chocolate effects on essential hypertension, serum lipid profile, inflammation and antioxidant markers in hypertensive patients taking losartan referring to health centers in Sabzevar

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170607034382N4

Enrollment

Registered

2020-10-07

Start date

2020-11-21

Completion date

Unknown

Last updated

2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension. Essential (primary) hypertension

Interventions

Intervention 1: Intervention group: Patients in the intervention group are asked to use vegetable chocolate three times in the morning, noon and evening instead of consuming sugar with daily tea. They

Eligibility

Sex/Gender

All

Age

30 Years to 65 Years

Inclusion criteria

Inclusion criteria: Hypertension ((systolic<160= 130) diastolic<100) = 85)) treatment with Losartan at least 3 months before starting the treatment plan. Do not use any drugs other than Losartan to control HTN Do not use other complementary or herbal medicines to control HTN Do not use a special diet to control high blood pressure or weight Lack of sensitivity to consuming chocolate containing cocoa Age between 30 and 65 years

Exclusion criteria

Exclusion criteria: ???? ??????? ?????? ??????? ? ??? ??????? ??? No heart disease, chronic lung disease and malignancies Do not take non-steroidal anti-inflammatory drugs Do not take blood cholesterol and triglyceride-lowering drugs Not heavy smoking

Design outcomes

Primary

Measure	Time frame
Mean reduction and standard deviation of blood pressure in patients with hypertension. Timepoint: Blood pressure at the end of 4, 8 and 12 weeks. Method of measurement: The patient's systolic and diastolic blood pressure in millimeters of mercury, while the patient is in a calm and stress-free environment for about 30 minutes, during which time he does not consume any caffeinated substances or cigarettes, in two turns five minutes apart by a mercury sphygmomanometer with a suitable cuff for the patient's body.;Decreased serum lipid profile in patients with hypertension. Timepoint: At the beginning and end of the study. Method of measurement: At the beginning of the project, 5 ml of fasting venous blood will be taken from the patients and the serum will be prepared by centrifugation at 3000 rpm for 5 minutes and will be kept in a -80 degree freezer to study biochemical factors. Then, in the end of study, a new sample will be taken again and studied.;Decreased serum C-Reactive Protein (CRP) in patients with hypertension. Timepoint: At the beginning and end of the study. Method of measurement: At the beginning of the project, 5 ml of fasting venous blood will be taken from the patients and the serum will be prepared by centrifugation at 3000 rpm for 5 minutes and will be kept in a -80 degree freezer to study biochemical factors. Then, in the end of study, a new sample will be taken again and studied.Serum CRP is measured by Enzyme-linked immunosorbent (ELISA).;Decreased serum malondialdehyde (MDA) and Total antioxidant capacity (TAC) in patients with hypertension. Timepoint: At the beginning and end of the study. Method of measurement: At the beginning of the project, 5 ml of fasting venous blood will be taken from the patients and the serum will be prepared by centrifugation at 3000 rpm for 5 minutes and will be kept in a -80 degree freezer to study biochemical factors. Then, in the end of study, a new sample will be taken again and studied.Serum TAC is measured by Ja	—

Measure

Time frame

Mean reduction and standard deviation of blood pressure in patients with hypertension. Timepoint: Blood pressure at the end of 4, 8 and 12 weeks. Method of measurement: The patient's systolic and diastolic blood pressure in millimeters of mercury, while the patient is in a calm and stress-free environment for about 30 minutes, during which time he does not consume any caffeinated substances or cigarettes, in two turns five minutes apart by a mercury sphygmomanometer with a suitable cuff for the patient's body.;Decreased serum lipid profile in patients with hypertension. Timepoint: At the beginning and end of the study. Method of measurement: At the beginning of the project, 5 ml of fasting venous blood will be taken from the patients and the serum will be prepared by centrifugation at 3000 rpm for 5 minutes and will be kept in a -80 degree freezer to study biochemical factors. Then, in the end of study, a new sample will be taken again and studied.;Decreased serum C-Reactive Protein (CRP) in patients with hypertension. Timepoint: At the beginning and end of the study. Method of measurement: At the beginning of the project, 5 ml of fasting venous blood will be taken from the patients and the serum will be prepared by centrifugation at 3000 rpm for 5 minutes and will be kept in a -80 degree freezer to study biochemical factors. Then, in the end of study, a new sample will be taken again and studied.Serum CRP is measured by Enzyme-linked immunosorbent (ELISA).;Decreased serum malondialdehyde (MDA) and Total antioxidant capacity (TAC) in patients with hypertension. Timepoint: At the beginning and end of the study. Method of measurement: At the beginning of the project, 5 ml of fasting venous blood will be taken from the patients and the serum will be prepared by centrifugation at 3000 rpm for 5 minutes and will be kept in a -80 degree freezer to study biochemical factors. Then, in the end of study, a new sample will be taken again and studied.Serum TAC is measured by Ja

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactRoghaye Javan

Sabzevar University of Medical Sciences

javanr911@mums.ac.ir+98 51 4422 0869

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026