Effects of positive end-expiratory pressure on hemodynamic status

Determining the effect of low positive end-expiratory pressure (PEEP) on hemodynamic status in patients undergoing gynecologic laparoscopy: A double-blinded clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201706057013N18

Enrollment

Registered

2017-06-28

Start date

2017-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic changes during gynecological surgery. Postprocedural disorders of circulatory system, not elsewhere classified

Interventions

Intervention 1: Intervention group: 40 patients will receive low PEEP with pressure of 5 cmHg, in addition to PPV. Intervention 2: Intervention group: 40 patients zero end-expiratory pressure, in addi

Treatment - Other

Intervention group: 40 patients will receive low PEEP with pressure of 5 cmHg, in addition to PPV.

Intervention group: 40 patients zero end-expiratory pressure, in addition to PPV.

Eligibility

Sex/Gender

Female

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: American society of Anesthesiology (ASA) class I; aged between 18-60 years old; candidate for laparoscopic gynecological surgery; interest to participate in study. Exclusion criteria: patients with ASA class II or higher; not inclined to take part in study; body mass index greater than 30 kg/m2; systemic disorders; psychotic disorders; emergent surgery; smokers; history of atopic disoders.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Heart rate. Timepoint: before induction of anesthesia, immediately after induction, at 5th,10th, 20th, 30th, 60th minutes and at the end of operation. Method of measurement: Questionnaire.;Systolic blood pressure. Timepoint: before induction of anesthesia, immediately after induction, at 5th,10th, 20th, 30th, 60th minutes and at the end of operation. Method of measurement: Questionnaire.;Dyastolic blood pressure. Timepoint: before induction of anesthesia, immediately after induction, at 5th,10th, 20th, 30th, 60th minutes and at the end of operation. Method of measurement: Questionnaire.;Arterial blood oxygen saturation. Timepoint: before induction of anesthesia, immediately after induction, at 5th,10th, 20th, 30th, 60th minutes and at the end of operation. Method of measurement: Questionnaire.	—

Measure

Time frame

Heart rate. Timepoint: before induction of anesthesia, immediately after induction, at 5th,10th, 20th, 30th, 60th minutes and at the end of operation. Method of measurement: Questionnaire.;Systolic blood pressure. Timepoint: before induction of anesthesia, immediately after induction, at 5th,10th, 20th, 30th, 60th minutes and at the end of operation. Method of measurement: Questionnaire.;Dyastolic blood pressure. Timepoint: before induction of anesthesia, immediately after induction, at 5th,10th, 20th, 30th, 60th minutes and at the end of operation. Method of measurement: Questionnaire.;Arterial blood oxygen saturation. Timepoint: before induction of anesthesia, immediately after induction, at 5th,10th, 20th, 30th, 60th minutes and at the end of operation. Method of measurement: Questionnaire.

—

Secondary

Measure	Time frame
Urinary output volume. Timepoint: At the end of operation. Method of measurement: Questionnaire.;Blood loss volume. Timepoint: At the end of operation. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Simin Atashkhoyi

Tabriz University of Medical Sciences

atashkhoii@tbzmed.ac.ir+98 41 3553 9161

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026